David Shis

Email: david.l.shis [at] rice.edu
Phone: +1 713.348.4393
April 2011 – Current

I’m broadly interested in synthetic biology. Putting together synthetic gene networks and seeing what happens is fun and cool! I am specifically interested on developing components for implementing synthetic gene networks and understanding gene network dynamics in a single cell.

Bachelor of Science: Bioengineering – UC Berkeley
Undergraduate Researcher: Clark Lab
Guest Researcher: Keasling Lab
Staff Research Associate: Joint Bioenergy Institute

1. Shis, D. L. & Bennett, M. R. "A library of synthetic transcriptional AND gates built with split T7 RNA polymerase mutants." Proc. Natl. Acad. Sci. 110 (13), 5028-5033 (2013).

2. Dietrich, J. A., Shis, D. L., Alikhani, A. & Keasling, J. D. Transcription Factor-Based Screens and Synthetic Selections for Microbial Small-Molecule Biosynthesis. ACS Synth. Biol. 2, 47-58 (2013).

3. C. M. Schmidt, D. L. Shis, T. D. Nguyen-Huu & M. R. Bennett, "Stable maintenance of multiple plasmids in E. coli using a single selective marker." ACS Synthetic Biology 1 (10), 445-450 (2012).

4. Bergeron L.M., Shis D.L., Gomez L., Clark D.S., “Small molecule inhibition of a Group II chaperonin: pinpointing a loop region within the equatorial domain as necessary for protein refolding”, Arch Biochem Biophys. 2009 Jan 1;481(1):45-51